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Long acting injectable medicine as a potential path to Covid-19 therapy

University of Liverpool

Researchers of the University of Liverpool have shown the potential to resume an existing and favorable drug in a long-term injectable therapy that could be used for the treatment of COVID-19.

In a magazine published in the magazine nanoscale nanoscale , researchers from the university center for long-acting therapeutics (Kelt) demonstrate the nanoparticle formulation of Niclosamid, a high-insoluble drug compound, as a scalable long-acting injectable antiviral candidate .

The team began to redesign identified drug connections with the potential for Covid-19 therapy candidates within weeks after first blocking. Niclosamid is just one of the identified drug compounds that are very effective in a series of laboratory studies for SARS-COV-2.

Use of your know-how in the areas of materials of chemistry, elevated drug delivery and pharmacology, Celt scientists used to form the nanoparticle formulations from redispersible solid medication nanoparticle formulations of Niclosamid. Her research has shown sustainably circulating drug concentrations which are maintained after a single injection for the duration of early infection.

Celt is with the Pharmacologist Professor Andrew Owen and Material Chemist Professor Steve Rannard at the University of Liverpool.

Professor Steve Rannard said, "The return-posing drug compounds is much more than existing medicines for a new disease. The existing active ingredient compound must be active at a significant level to be active at a significant level and then reformulated to new To address challenges. The conventional route of administration can not be relevant and change the way the patient receives the active ingredient compound is extremely critical for the effectiveness. Niclosamid is an ideal candidate that is evaluated as a potential long, injectable therapeutic therapeuticism To treat COVID-19.

"This is still in the former stage development, but the Celt team is currently working with a contract manufacturing organization to take this in the direction of scaling and clinical production. This work is well advanced, and when successful, human attempts are next. See you a future "test-and-treat scenario" in which infected persons are treated at the diagnostic point with the full therapy course in an injection. "

Professor Andrew Owen said: "The re-tracking of medications for SARS-COV-2 has achieved mixed results, with some clear success for immunomodulatory medicines such as dexamethasone and work to drugs like Favipiravir and Molnupiravir designed for other viruses.

"The ultimate usefulness of our long-acting injectable, can only be determined in properly driven and well-controlled randomized clinical trials, but in contrast to other drugs, which can be achieved in humans for exploring the drum of Niclosamid target concentrations. The Formulation has shown greatly demonstrated in the preclinical studies at a time when it is increasingly obvious that drugs are urgently needed to supplement the vaccines.

"A global pandemic requires a global solution, and it is critical that the interventions are available to anyone and not the privileged few. Accordingly, we are currently working to remove obstacles to the availability in the low and medium-sized countries countries just access, if the clinical success is ultimately demonstrated. "

This research paper builds on earlier reports released from the team in April 2020 and published in clinical pharmacology and therapeutics.The Celt team was strongly advocated in other publications in the British Journal of Clinical Pharmacology that the re-tracking of drugs requires new strategies that include reformulating and specific dose optimization that deals with the requirements of SARS COV-2 treatment.

Celt focuses on resuming existing medicines in slow formulations in which the effectiveness of drugs can maintain over several months. This stunning technology has already been successfully implemented in the areas of prevention and schizophrenia. It also has the potential to strengthen global efforts to attack - and even significant diseases relating to low and medium-sized countries, including HIV / AIDS.

The team's many years of therapy development has been initiated and supported by funds from the EPSRC, and the progress for the scaling and manufacture has received support from unitalized. The team actively seeks partner for the next steps of product development and translation.

£ £ 30.5 million (USD $ 40 million) International Research Consortium, mainly financed by UnitalAd, is the first of its kind in the world. For more information, please visit the CELT website. You can also follow the center on Twitter.

The paper `scalable nanophanitation of Niclosamid and in vivo demonstration of long-term delivery after intramuscular injection '(DOI: 10.1039 / D1NR00309G) is published in nanoscale .

Disclaimer: AAAs and Eurecalert! Are not responsible for the accuracy of news publications at EURECALERERT! Through contributions from institutions or to the use of information about the Eurecalert system.

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